PLATELET-ACTIVATING-FACTOR RECEPTOR-ANTAGONIST (BN-52021) STABILIZES THE OXIDATIVE-ANTIOXIDATIVE BALANCE AND ATTENUATES THE MORPHOLOGICAL-CHANGES IN THE GASTROINTESTINAL-TRACT IN EXPERIMENTAL HEMORRHAGIC-SHOCK

The influence of the platelet-activating factor receptor-antagonist (B N 52021) and polyelectrolyte solution (PES) on the morphology and oxid ant-antioxidant equilibrium in the gastrointestinal wall in hemorrhagi c shock was examined in rats. The animals were divided into five group s: I control, II - sham operation, III - untreated hemorrhagic shock l asting 75 minutes, IV - shock treated with PES, and V - shock treated with BN 52021 and PES. The most expressed morphological changes were f ound in the small intestine in group IV (shock treated with PES) and i n group III (untreated shock). Morphological changes were well correla ted with the malondialdehyde (MDA) level reflecting oxidative tissue i njury and with the antioxidative potential: sulfhydryl compounds (-SH) level, and superoxide dismutase (SOD) activity. The signs of morpholo gical and biochemical injury to the gastrointestinal tract in animals from group V (treated with BN 52021 and PES) were significantly less e xpressed than those in groups III and IV. The results suggest an essen tial role of PAF in oxygen radicals mediated gastrointestinal injury a nd a beneficial effect of the early application of BN 52021 in hemorrh agic shock.