Tetraploid or near-tetraploid karyotype has been described rarely in h
ematologic neoplasms. Herein we report two nerv cases of adult acute m
yeloblastic leukemia, MO and M1 FAB subtypes that showed near-tetraplo
id clones that were studied with conventional cytogenetics and in situ
hybridization (ISH). We compare our new cases with those previously r
eported. (C) Elsevier Science Inc., 1998.