GASTROINTESTINAL STROMAL TUMOR, UNCOMMITTED TYPE, WITH MONOSOMY-14 AND MONOSOMY-22 AS THE ONLY CHROMOSOMAL-ABNORMALITIES

Authors
MARCI V CASORZO L SAROTTO I DOGLIANI N MILAZZO MG RISIO M
Citation
V. Marci et al., GASTROINTESTINAL STROMAL TUMOR, UNCOMMITTED TYPE, WITH MONOSOMY-14 AND MONOSOMY-22 AS THE ONLY CHROMOSOMAL-ABNORMALITIES, Cancer genetics and cytogenetics, 102(2), 1998, pp. 135-138
Citations number
15
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
102
Issue
2
Year of publication
1998
Pages
135 - 138
Database
ISI
SICI code
0165-4608(1998)102:2<135:GSTUTW>2.0.ZU;2-U
Abstract
Karyotypic analysis of a gastric stromal tumor with the histologic and immunohistochemical features of a malignant, uncommitted lesion revea led clonal monosomies of chromosomes 14 and 22. Such changes, together with loss of chromosomes 15 and 18, as well as structural rearrangeme nts involving chromosome 1, have been previously reported in gastroint estinal stromal tumors with smooth muscle differentiation. We suggest that monosomies of chromosomes 14 and 22 are early events in the malig nant transformation of the mesenchymal cell-originating gastrointestin al stromal tumors. (C) Elsevier Science Inc., 1998.