A 49-year-old woman presented with splenic lymphoma with villous lymph
ocytes (SLVL) that showed a clonal abnormality of del(7)(q22q32) in ad
dition to inv(10)(p13q23), the latter being a previously undescribed a
bnormality in chronic lymphoproliferative disorders. A review of the l
iterature on cytogenetic abnormalities of SLVL indicates that del(7q)
is strongly associated with SLVL and may be important in the pathogene
sis of this disorder. (C) Elsevier Science Inc., 1998.