2D H-1 AND C-13 NMR EVIDENCE FOR STEREOSELECTIVE FORMATION OF A NEW BOND C-N, C-S OR C-C IN THE REACTION OF IVALIN ACETATE WITH SUBSTITUTEDPYRIMIDINES

Authors
DIAZ E NAVA JL BARRIOS H QUIROZ B GUZMAN A LEON L FUENTES A
Citation
E. Diaz et al., 2D H-1 AND C-13 NMR EVIDENCE FOR STEREOSELECTIVE FORMATION OF A NEW BOND C-N, C-S OR C-C IN THE REACTION OF IVALIN ACETATE WITH SUBSTITUTEDPYRIMIDINES, SPECT ACT A, 54(4), 1998, pp. 567-574
Citations number
21
Categorie Soggetti
Spectroscopy
Journal title
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN journal
13861425 → ACNP
Volume
54
Issue
4
Year of publication
1998
Pages
567 - 574
Database
ISI
SICI code
1386-1425(1998)54:4<567:2HACNE>2.0.ZU;2-1
Abstract
Several pyrimidine derivatives of ivalin acetate were synthesized as p otential anti HIV agents. High stereoselective Michael addition to iva line acetate was observed and a new C-C, C-N or C-S bond was formed. 2 D NMR H-1 and C-13 as well as X-ray crystallographic studies were perf ormed on the compounds herein described to establish the structure and stereochemistry. (C) 1998 Elsevier Science B.V. All rights reserved.