The Stratospheric Observatory for Infrared Astronomy (SOFIA) is a modi
fied Boeing 747-SP equipped with a 2.5 m telescope dedicated to astron
omical research. Currently under joint development by the US (NASA) an
d Germany (DLR), it is scheduled to begin operations in late 2001. The
ability of SOFIA to carry out its mission will depend strongly on the
meteorological conditions at and above flight altitudes in the vicini
ty of its home base. The most important meteorological factors are the
frequency of high-altitude clouds and the magnitude of the water vapo
r overburdens. This paper performs a high-altitude site survey by gath
ering together the best available meteorological data, defining metric
s, and evaluating them for a variety of sites. These metrics are found
to corroborate past airborne experience and to be consistent with wel
l-known global circulation patterns, convection, and upper tropospheri
c dynamics. They indicate that I:here are significant variations in th
e weather at SOFIA flight altitudes. Particularly in summer, some cont
inental US sites are shown to be worse than Hawaii, where high-altitud
e cirrus clouds and the associated moisture have historically caused s
ignificant losses in the amount and quality of the astronomical data c
ollected by NASA's Kuiper Airborne Observatory. SOFIA's planned home b
ase, Moffett Field? CA, is found to have excellent high-altitude weath
er and to be one of the best continental US sites.