RECENT TRENDS IN ENZYMATIC CONVERSION OF CEPHALOSPORIN-C TO 7-AMINOCEPHALOSPORANIC ACID (7-ACA)

Authors
PARMAR A KUMAR H MARWAHA SS KENNEDY JF
Citation
A. Parmar et al., RECENT TRENDS IN ENZYMATIC CONVERSION OF CEPHALOSPORIN-C TO 7-AMINOCEPHALOSPORANIC ACID (7-ACA), Critical reviews in biotechnology, 18(1), 1998, pp. 1-12
Citations number
55
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Critical reviews in biotechnology → ACNP
ISSN journal
07388551
Volume
18
Issue
1
Year of publication
1998
Pages
1 - 12
Database
ISI
SICI code
0738-8551(1998)18:1<1:RTIECO>2.0.ZU;2-A
Abstract
7-Aminocephalosporanic acid (7-ACA) is the basic building block used i n the synthesis of many important semisynthetic cephalosporin antibiot ics that are of current interest in the biopharmaceutical industry wit h a share of about 29% of the estimated worldwide antibiotic market. T his article describes the important recent developments for the biosyn thesis of 7-Aminocephalosporanic acid (7-ACA) from cephalosporin C usi ng the enzymatic route. Details of purification, stability, and immobi lization of the enzymes used for this biotransformation are also descr ibed.