THE USE OF BAKERS-YEAST IN THE GENERATION OF ASYMMETRIC CENTERS TO PRODUCE CHIRAL DRUGS AND OTHERS COMPOUNDS

This review gives a general idea about the importance of chiral carbon in medicine and a way to obtain chiral building blocks with baker's y east (Saccharomyces cerevisiae) or synthesis of medicaments and other organic compounds. Reactions with these microorganisms are cheaper and easier to be executed than with chemicals (for example, organometalli cs). Examples of important and practical reactions catalyzed by enzyme s inside Saccharomyces cerevisiae are given and probable mechanisms of action of these enzymes are shown. Although these microbes have advan tages such as low cost and availability, there are some cares that are necessary to be taken, like NAD(P)H dosage to choose strains more ade quate for reduction reactions.