SAAM-II - SIMULATION, ANALYSIS, AND MODELING SOFTWARE FOR TRACER AND PHARMACOKINETIC STUDIES

Kinetic analysis and integrated systems modeling have contributed subs tantially to our understanding of the physiology and pathophysiology o f metabolic systems and the distribution and clearance of drugs in hum ans and animals. In recent years, many researchers have become aware o f the usefulness of these techniques in the experimental design, With this has come the recognition that the discipline of kinetic analysis requires its own expertise, The expertise can impact experimental desi gn in many ways, from the collaborative and service activities in whic h individuals interact in formal ways to the development of software t ools to aid in kinetic analysis. The purpose of this report is to desc ribe one such software tool, Simulation, Analysis, and Modeling Softwa re II (SAAM II). In the first part, we describe in general how the use r can take advantage of the capabilities of the software system, and i n the second part, we give three specific examples using multicompartm ental models found in lipoprotein (apolipoprotein B [apoB] kinetics) a nd diabetes (glucose minimal model) research. Copyright (C) 1998 by W. B. Saunders Company.