TOTAL SYNTHESIS OF ANGUCYCLINES - 9 - AN ALTERNATIVE BIOMIMETIC-TYPE SYNTHESIS OF 8-DEOXYTETRANGOMYCIN

Authors
KROHN K HAYAT N
Citation
K. Krohn et N. Hayat, TOTAL SYNTHESIS OF ANGUCYCLINES - 9 - AN ALTERNATIVE BIOMIMETIC-TYPE SYNTHESIS OF 8-DEOXYTETRANGOMYCIN, Journal fur praktische Chemie, Chemiker-Zeitung, 340(2), 1998, pp. 171-174
Citations number
12
Categorie Soggetti
Chemistry,"Chemistry Applied
Journal title
Journal fur praktische Chemie, Chemiker-Zeitung → ACNP
ISSN journal
09411216
Volume
340
Issue
2
Year of publication
1998
Pages
171 - 174
Database
ISI
SICI code
0941-1216(1998)340:2<171:TSOA-9>2.0.ZU;2-Z
Abstract
Base-catalyzed cyclization of the naphthoquinone 5 afforded the 1,2-di hydroanthraquinone 6a. The bisallcylation products 9 and 10 were obtai ned by Stille-type chain elongation of the corresponding triflate 6b w ith the stannanes 7 or 8. The dihydroanthraquinone 9 is a potential pr ecursor for the SS-228 Y-type angucyclinones, where as the diketone 10 can be converted to 8-deoxytetrangomycin (11).