F. Gebauer et al., NOVEL FUNCTIONS FOR NUCLEAR FACTORS IN THE CYTOPLASM - THE SEX-LETHALPARADIGM, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 8(6), 1997, pp. 561-566
In recent years, novel functions for a number of nuclear factors have
been uncovered in the cytoplasm, mainly at the level of translation. T
hese factors behave as multifunctional regulators of gene expression a
nd many play key roles in cell differentiation and development. One of
the best characterized examples is that of Sex-lethal (SXL) an RNA-bi
nding protein that is expressed in female Drosophila flies and control
s sex determination and dosage compensation. Recent findings indicate
that SXL, a paradigmatic regulator of splicing also controls translati
on of target mRNAs. This review attempts to summarize this evidence an
d provide an overview of 'nuclear factors' with roles in translation.
(C) 1997 Academic Press Ltd.