AN EFFICIENT SYNTHESIS OF 17-EPI-ETHYNYLESTRADIOL

Authors
EWERS CLJ HARRE M MOHR J NICKISCH K TILSTAM U
Citation
Clj. Ewers et al., AN EFFICIENT SYNTHESIS OF 17-EPI-ETHYNYLESTRADIOL, Tetrahedron, 54(17), 1998, pp. 4277-4282
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
17
Year of publication
1998
Pages
4277 - 4282
Database
ISI
SICI code
0040-4020(1998)54:17<4277:AESO1>2.0.ZU;2-0
Abstract
An efficient synthesis has been developed yielding 17-epi-ethynylestra diol 2 in an overall yield of 17%. The key derivatives 7a-c were prepa red from estrone in four steps. Subsequently epoxides 7a,c were effici ently transformed into 2 via Takano's method. (C) 1998 Elsevier Scienc e Ltd. All rights reserved.