GENETIC SPECIFICITY OF STRESS-INDUCED ANEMIA IN RATS

There is a genetic difference in rat hemoglobin (Hb) beta-chain struct ure, with alternate alleles, A and B, at a single locus. This study wa s designed to find out whether marrow sensitivity due to gamma exposur e and experimentally induced anemia in age-matched adult rats is entir ely strain specific or is a combination of both strain and Hb genotype . Eight strains of inbred and outbred mts comprising AA and BB types w ere examined. The data indicate that there is a relationship between m arrow sensitivity and Hb genotypes in response to erythropoietic stres s caused by three techniques.