ISOLATION OF A BIOACTIVE CA2-MOBILIZING COMPLEX LIPID FROM BOVINE VITREOUS BODY()

Authors
CAMINA JP CASABIELL XA PEREZ FR LAGE M CASANUEVA FF
Citation
Jp. Camina et al., ISOLATION OF A BIOACTIVE CA2-MOBILIZING COMPLEX LIPID FROM BOVINE VITREOUS BODY(), Biochemical and biophysical research communications, 244(3), 1998, pp. 696-700
Citations number
25
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
244
Issue
3
Year of publication
1998
Pages
696 - 700
Database
ISI
SICI code
0006-291X(1998)244:3<696:IOABCC>2.0.ZU;2-E
Abstract
Vitreous body extracts show a potent Ca2+-mobilizing activity on fibro blast cells. This Ca2+ signal is complex, and due to the presence of t wo different bioactive substances. The first one was identified as aci d FGF. The second one was shown to be a low molecular weight substance identified as a complex lipid by a combination of chromatographic and biochemical data. This finding raises the possibility that non-classi cal substances with growth factor-like activity might play a role in t he regulation of proliferative processes in the eye. (C) 1998 Academic Press.