OPSONO-RECOGNITION OF LIPOSOMES BY TISSUE MACROPHAGES

On exposure to blood, liposomes of different morphology and lipid comp osition attract different arrays of proteins. The mode of interaction of blood proteins with liposomes vary in quantity and conformation. Th ese differences may explain different observed patterns in blood clear ance and tissue distribution of liposomes. In this paper, an attempt i s made to assess the role of serum and its components in regulating li posome recognition by isolated phagocytes of rat liver and spleen. (C) 1998 Elsevier Science B.V. All rights reserved.