LIPID-PEROXIDATION PRODUCTS AND ANTIOXIDANT CAPACITY IN PORTAL VENOUSAND SYSTEMIC ARTERIAL PLASMA DURING GRADUAL INTESTINAL ISCHEMIA AND REPERFUSION IN PIGS

Intestinal ischemia may evoke an inflammatory response and eventually multiple organ failure. We investigated whether intestinal ischemic in jury induces systemic lipid peroxidation and changes in the plasma ant ioxidant capacity in a pig model. Together with cardiovascular paramet ers, arterial and portal venous blood of 7 pigs were measured for thio barbituric acid-reactive material diene conjugates, fluorescent chromo lipids and plasma antioxidant capacity during graded occlusion of supe rior mesenteric artery and reperfusion, Plasma levels of lipid peroxid ation products did not change significantly during graded ischemia and reperfusion. Portal venous plasma antioxidant capacity increased slig htly during reperfusion (from 96.16 +/- 3.91 to 142.49 +/- 12.01 mu mo l/l, p < 0.05). Although elevated levels of free radical reaction prod ucts have been found in ischemia-reperfusion, we found no evidence of systemic lipid peroxidation in our intestinal ischemia model.