Y. Levy et al., EFFECT OF OMENTAL ANGIOGENIC LIPID FACTOR ON REVASCULARIZATION OF AUTOTRANSPLANTED SPLEEN IN DOGS, European surgical research, 30(2), 1998, pp. 138-143
Since the turn of the century, studies have been carried out showing t
hat the omentum contains a factor which enhances revascularization of
ischemic tissues, This study was conducted for a period of 3 months an
d was designed to evaluate the effect of an omental lipid fraction on
neovascularization of autotransplanted spleen chips in dogs, Twelve do
gs underwent splenectomy and autotransplantation of 5 splenic chips in
to an omental pouch, In 4 dogs, the splenic chips were immersed in ome
ntal angiogenic lipid factor (OAF), while on another 3 dogs, an intram
uscular injection of 4 cm(3) of OAF was given each day for 7 days post
operatively, a further 4 dogs were not given any of the above treatmen
ts (control group), Serial angiographies and histologic examinations d
emonstrated better neovascularization and regeneration of the transpla
nted spleen in the dogs from the immersion plus injection group. These
data suggest that the omental lipid fraction contains a factor which
induces a better regeneration of splenic transplants.