PRO-NUCLEOTIDES - RECENT ADVANCES IN THE DESIGN OF EFFICIENT TOOLS FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE NUCLEOSIDE MONOPHOSPHATES

A summary of the most recent advances to the design of pronucleotides will be presented. Approaches that have been designed to be activated by enzymes such as carboxyesterases [bis(POM)-, bis(POC)-, bis(SATE)-, bis(AB) phosphotriesters and the arylphosphoramidates] or by reductas es [bis(SDTE) approach] will be discussed as well as the amino acids p hosphoramidate diester concept with its still unknown delivery mechani sm and the cycloSal approach that releases the nucleotides by an induc ed tandem reaction.