AN EFFICIENT AND FACILE SYNTHESIS OF NOVEL 3-BENZOYL-3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDINES

The condensation of 1-aryl-2-dimethylaminomethylprop-2-en-1-ones 4 wit h 2-aminopyridines 5 gives rise to the 3-benzoyl-3,4-dihydro-2H-pyrido [1,2-a]pyrimidines 3. The reaction is initiated by addition of the pyr idine amino group to the enone double bond, followed by deamination an d ring closure to give the anellated pyrimidine ring system, which is an excellent precursor for the synthesis of pharmacological active com pounds.