POLY(ETHYLENE GLYCOL) SUPPORTED LIQUID-PHASE SYNTHESIS OF BIARYLS

The liquid phase synthesis of biaryls via Suzuki cross-coupling reacti on on poly(ethylene glycol) supports (PEGs) is described. The reaction is exemplified by parallel coupling of polymer bound aryl halides wit h boronic acids. Four different PEGs were employed as soluble polymer supports for parallel synthesis. The generated libraries include both sterically hindered aryl halides (2b, 2d) and boronic acids. The react ions were run in the homogeneous phase and the synthetic sequences per formed in parallel fashion. Quantitative conversion in the Suzuki coup lings was verified by H-1-NMR analysis (3a-r). The polymer bound produ cts were isolated in good to excellent (52% to 98%) yields by either s imple precipitation of the soluble support or column filtration.