IDENTIFICATION OF P53 AND HUMAN PAPILLOMA-VIRUS IN SCHNEIDERIAN PAPILLOMAS

Schneiderian papilloma of the nose is an unusual neoplasm with the pro pensity for local tissue destruction, recurrence, and malignant degene ration, Human papilloma virus (HPV) is related to a subset of sinonasa l papillomas and has been implicated in the pathogenesis of cancer by interaction with the host p53 protein, Detection of p53 and HPV could be clinically useful as tumor markers for lesions with oncogenic poten tial, Thirty specimens for p53 were studied and nine (30%) stained pos itive, HPV was detected in six (20%), In the presence of p53, an odds ratio for carcinoma was 1.19:1, or 19% higher than expected, In the pr esence of HPV the odds ratio for carcinoma was 11.5:1, or 11.5 times h igher than expected. In the presence of HPV an odds ratio for finding an elevated amount of p53 was 2.2:1, The data support the hypothesis t hat HPV and p53 may interact in a novel manner and elevate the risk fo r neoplasia.