EFFECT OF INTRATYMPANIC STEROID APPLICATION ON THE DEVELOPMENT OF EXPERIMENTAL CHOLESTEATOMA

By introducing certain irritants into the middle ear it is possible to produce cholesteatoma, Propylene glycol, the main agent used for this purpose, produces a long-standing inflammation that causes hyperplasi a and migration of the epithelium through an intact tympanic membrane, In the present investigation topical prednisolone was used in order t o inhibit the production of cholesteatoma, The results indicate that t here is a marked decrease in inflammation and hence experimental chole steatoma production when prednisolone is administered into the middle ear.