STERILIZATION OF UNLOADED POLYBUTYLCYANOACRYLATE NANOPARTICLES

In this study the possibilities of sterilizing polybutylcyanoacrylate nanoparticle suspensions and lyophilized nanoparticle powders by autoc laving or formaldehyde treatment was evaluated. The nanoparticles were fabricated with different stabilizers. In most conditions a significa nt increase in particle size was determined after autoclaving of the n anoparticle suspensions and the nanoparticle powders were characterize d by impaired resuspension characteristics. Even if the sterilization of nanoparticles after fabrication is possible under certain condition s, the preferable way to obtain aseptic material appears to be the pro duction of nanoparticles under aseptic conditions. (C) 1998 Elsevier S cience B.V. All rights reserved.