EFFICACY OF SULFAMETHOXYPYRIDAZINE IN A MURINE MODEL OF PNEUMOCYSTIS-CARINII PNEUMONIA

Authors
BARTLETT MS SHAW MM SMITH JW MESHNICK SR
Citation
Ms. Bartlett et al., EFFICACY OF SULFAMETHOXYPYRIDAZINE IN A MURINE MODEL OF PNEUMOCYSTIS-CARINII PNEUMONIA, Antimicrobial agents and chemotherapy, 42(4), 1998, pp. 934-935
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
4
Year of publication
1998
Pages
934 - 935
Database
ISI
SICI code
0066-4804(1998)42:4<934:EOSIAM>2.0.ZU;2-5
Abstract
Sulfamethoxazole is the component of co-trimoxazole responsible for it s efficacy against Pneumocystis carinii pneumonia, but this drug is as sociated with frequent adverse effects. Sulfamethoxypyridazine is sign ificantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patient s.