IN-VITRO AND IN-VIVO ANTIDERMATOPHYTE ACTIVITIES OF NND-502, A NOVEL OPTICALLY-ACTIVE IMIDAZOLE ANTIMYCOTIC AGENT

In vitro and in vivo antidermatophyte activities of NND-502, a new imi dazole antimycotic agent, were compared with those of two existing ant ifungal agents, lanoconazole and terbinafine. NND-502 exhibited strong in vitro antifungal activity against Trichophyton spp.; its MIC was 1 to 4 times lower than that of lanoconazole or terbinafine. In an in v ivo study with a guinea pig model of tinea pedis, 7-day topical treatm ent with a 0.5% solution of NND-502 (dissolved in polyethylene glycol 400) was more effective than that with a 0.5% solution of either lanoc onazole or terbinafine for eradicating fungi from the infected feet. W hen the duration of treatment was shortened to 3 days, a topical 1% so lution of NND-502 achieved a complete mycological cure, while topical 1% solutions of lanoconazole and terbinafine did not.