IN-VITRO ACTIVITY OF LEVOFLOXACIN AGAINST A SELECTED GROUP OF ANAEROBIC-BACTERIA ISOLATED FROM SKIN AND SOFT-TISSUE INFECTIONS

The in vitro activity of levofloxacin was compared to the activities o f ofloxacin, ciprofloxacin, ampicillin-sulbactam (2:1), cefoxitin, and metronidazole for a selected group of anaerobes (n = 175) isolated fr om skin and soft tissue infections by using the National Committee for Clinical Laboratory Standards-approved Wadsworth method. Ampicillin s ulbactam and cefoxitin inhibited 99% of the strains of this select gro up, levofloxacin and ofloxacin inhibited 73 and 50%, respectively, at 2 mu g/ml, and ciprofloxacin inhibited 51% at 1 mu g/ml. The geometric mean MIC of levofloxacin was lower than those of ofloxacin and ciprof loxacin for every group except Veillonella.