K. Nario et al., EFFECT OF ENDOPLASMIC CA2-ATPASE INHIBITORS ON COCHLEAR POTENTIALS INTHE GUINEA-PIG(), Acta oto-laryngologica, 118(2), 1998, pp. 198-205
The effect of endoplasmic Ca2+-ATPase inhibitors on cochlear potential
s was examined iii the guinea-pig. Perilymphatic perfusion with thapsi
gargin (10(-6) M) produced a significant decrease in tile amplitudes o
f cochlear microphonics, negative summating potential and compound act
ion potential, and a significant prolongation of N-1 latency with Ilo
change iu the endocochlear potential. These changes were all dose depe
ndent. Another endoplasmic Ca2+-ATPase inhibitor, cyclopiazonic acid (
10(-5) M), produced the same effects as thapsigargin on cochlear poten
tials. These results suggest that endoplasmic Ca2+-ATPase inhibitors m
ay have inhibitory functions on cochlear potentials.