CLONING, SEQUENCING AND STRUCTURAL-ANALYSIS OF 976 BASE-PAIRS OF THE PROMOTER SEQUENCE FOR THE RAT LIPOPROTEIN-LIPASE GENE - COMPARISON WITH THE MOUSE AND HUMAN SEQUENCES

Authors
BEY L ETIENNE J TSE C BRAULT D NOE L RAISONNIER A ARNAULT F HAMILTON MT GALIBERT F
Citation
L. Bey et al., CLONING, SEQUENCING AND STRUCTURAL-ANALYSIS OF 976 BASE-PAIRS OF THE PROMOTER SEQUENCE FOR THE RAT LIPOPROTEIN-LIPASE GENE - COMPARISON WITH THE MOUSE AND HUMAN SEQUENCES, Gene, 209(1-2), 1998, pp. 31-38
Citations number
23
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
209
Issue
1-2
Year of publication
1998
Pages
31 - 38
Database
ISI
SICI code
0378-1119(1998)209:1-2<31:CSASO9>2.0.ZU;2-M
Abstract
We cloned and sequenced the -976 bp promoter of the rat lipoprotein li pase LPL gene. The sequence was compared with the mouse and human sequ ences. The homology between the rat and mouse LPL tucleotide sequences was not quite as strong in the promoter sequence as in the coding seq uence. Among the 976 nt promoter there were 118 divergences, i.e. 11.8 %, compared to only 5.6% for the LPL coding region. However, within th e 200 nt immediately 5' to the transcriptional start site (proximal pr omoter), the divergence was only 4%. New potential cis-elements (such as (CACCC, GATA, GC and GA boxes, IRS, Krox, MEF 2, E-box, CCArGG and 1/2 VDRE) were identified in the rat, mouse or human LPL gene. (C) 199 8 Elsevier Science B.V.