STEREOSELECTIVE REDUCTION OF (+ -)-BICYCLO[3.3.1]NONANE-2,6-DIONE BY MICROORGANISMS/

Authors
MIYAZAWA M NOBATA M OKAMURA S MURAOKA O TANABE G KAMEOKA H
Citation
M. Miyazawa et al., STEREOSELECTIVE REDUCTION OF (+ -)-BICYCLO[3.3.1]NONANE-2,6-DIONE BY MICROORGANISMS/, Journal of chemical technology and biotechnology, 71(4), 1998, pp. 281-284
Citations number
9
Categorie Soggetti
Engineering, Chemical",Chemistry,"Biothechnology & Applied Migrobiology
Journal title
Journal of chemical technology and biotechnology → ACNP
ISSN journal
02682575
Volume
71
Issue
4
Year of publication
1998
Pages
281 - 284
Database
ISI
SICI code
0268-2575(1998)71:4<281:SRO(-B>2.0.ZU;2-C
Abstract
The biotransformation of (+/-)-bicyclo[3.3.1]nonane-2,6-dione by Asper gillus niger and Glomerella cingulara was investigated. The diketone w as reduced to the ketoalcohol 2-endo-hydroxy-bicyclo[3.3.1]nonane-6-on e and the diol endo,endo-bicyclo[3.3.1]nonane-2,6-diol respectively. E ndo,endo-bicyclo[3.3.1]nonane-2,6-diol and ketoalcohols produced by G. cingulata had high optical purity, on the other hand, reduction by A. niger yielded optically active (-)-(1R, 2S, 5R, 6S)-bicyclo[3.3.1]non ane-2,6-diol(99.9% e.e.). (C) 1998 SCI.