KERATOSIS-FOLLICULARIS SPINULOSA DECALVANS - CONFIRMATION OF LINKAGE TO XP22.13-P22.2

Keratosis follicularis spinulosa decalvans (KFSD) is a rare, X linked disorder with skin and eye involvement: (MIM 308800). We have studied a large British family with KFSD using polymorphic markers from Xp21-p 23 and obtained a lod score of 2.056 at theta=0 with markers proximal and distal to the KFSD candidate region Xp22.13-p22.2 identified by Oo sterwijk et al. Our data confirm the linkage to Xp22.13-p22.2 observed in the previously reported Dutch family, but fail to narrow the candi date interval for the KFSD locus.