REDUNDANT DOWN-REGULATION PATHWAYS FOR P53

Authors
CINELLI M MAGNELLI L CHIARUGI V
Citation
M. Cinelli et al., REDUNDANT DOWN-REGULATION PATHWAYS FOR P53, Pharmacological research, 37(2), 1998, pp. 83-85
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacological research → ACNP
ISSN journal
10436618
Volume
37
Issue
2
Year of publication
1998
Pages
83 - 85
Database
ISI
SICI code
1043-6618(1998)37:2<83:RDPFP>2.0.ZU;2-T
Abstract
The aim of this review is to underline the redundancy of down-regulati on pathways for p53, at the light of the two more important degradativ e systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-ba ck loop is also illustrated, as well as the phosphorylative/dephosphor ylative regulation of the latent and active p53 isoforms. The mechanis ms prolonging p53 half life, following irradiation, are also discussed . (C) 1998 The Italian Pharmacological Society.