CORRELATION OF PROSTATE-SPECIFIC ANTIGEN IMMUNOREACTIVITY (IR-PSA) TOOTHER PROGNOSTIC FACTORS IN FEMALE BREAST-CANCER

Recently, using an ultrasensitive time-resolved immuno-fluorometric as say, PSA immunoreactivity (IR-PSA) was found in breast tumor cytosols. We retrospectively studied 219 breast cancer patients measuring IR-PS A in the tumor cytosols, and classified the breast cancers as either P SA positive or PSA negative based on an IR-PSA cutoff level of 1pg/mg. Multivariated analysis showed that IR-PSA is an independent favourabl e prognostic indicator for postmenopausal, node positive breast cance patients. Additionally, IR-PSA correlates with reduced risk of relapse in ER+nu e tumors and is negatively correlated with mutated p53, whic h increases the risk of relapse.