Ach. Gordon et al., ACUTE EXACERBATION OF VASCULITIS DURING INTERFERON-ALPHA THERAPY FOR HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA, The Journal of infection, 36(2), 1998, pp. 229-230
A significant, previously unreported, adverse reaction to interferon-a
lpha therapy is reported, Immediately after the commencement of low do
se therapy a man with hepatitis-C associated cryoglobulinaemia develop
ed a purpuric rash and a severe, reversible impairment of renal functi
on. This observation may elucidate the immunopathogenesis of vasculiti
s.