We report a solitary leiomyoma of the superior mesenteric artery resul
ting in arterial occlusion and gangrenous bowel. On histologic evaluat
ion the lesion extended into the vessel lumen off its stalk and showed
immunostaining for smooth muscle antigen and desmin. Leiomyomas can a
rise anywhere there is smooth muscle and occur most commonly in the ut
erus followed by the skin and gastrointestinal tract. We could not ide
ntify any previous case in the literature of a leiomyoma arising from
within the wall of a mesenteric vessel.