POTENTIAL INHIBITORS OF PLASMODIAL HEME OXYGENASE - AN INNOVATIVE APPROACH FOR COMBATING CHLOROQUINE-RESISTANT MALARIA

Authors
SRIVASTAVA P PANDEY VC MISRA AP GUPTA P RAJ K BHADURI AP
Citation
P. Srivastava et al., POTENTIAL INHIBITORS OF PLASMODIAL HEME OXYGENASE - AN INNOVATIVE APPROACH FOR COMBATING CHLOROQUINE-RESISTANT MALARIA, Bioorganic & medicinal chemistry, 6(2), 1998, pp. 181-187
Citations number
17
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
2
Year of publication
1998
Pages
181 - 187
Database
ISI
SICI code
0968-0896(1998)6:2<181:PIOPHO>2.0.ZU;2-3
Abstract
Syntheses of imidazo-pyridines and substituted prolines and their effe ct on heme oxygenase activity of Plasmodium yoelii and corresponding i nfected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further e xploited in the development of resistant reversal agents. (C) 1998 Els evier Science Ltd. All rights reserved.