Jd. Dinman et al., TRANSLATING OLD DRUGS INTO NEW TREATMENTS - RIBOSOMAL FRAMESHIFTING AS A TARGET FOR ANTIVIRAL AGENTS, Trends in biotechnology, 16(4), 1998, pp. 190-196
Programmed ribosomal frameshifting is used by many viruses to regulate
the production of structural and enzymatic proteins. Altering the fra
meshifting efficiencies disrupts the virus life cycle and eliminates o
r reduces virus production, Ribosomal frameshifting therefore provides
a unique target on which antiviral agents can function, This article
describes a series of rapid assay strategies that have been developed
and used to identify potential antiviral agents that target programmed
-1 ribosomal frameshifting.