We tested a nurse clinician-mediated intervention to relieve pain in a
group of seriously ill hospitalized adults using a randomized control
led trial at five tertiary care academic centers in the US. The study
included 4804 patients admitted between January 1992 and January 1994
with one or more of nine high mortality diagnoses; 2652 were allocated
to the intervention and 2152 to usual care. Specially-trained nurse c
linicians assessed patients' pain, educated them and their families ab
out pain control, empowered patients to expect pain relief, informed p
atients' nurses and physicians about level of pain and suggested or us
ed other pain management resources, Patients' pain was determined from
hospital interviews with patients and surrogates. Pain 2 and 6 months
later or after death and satisfaction with its control at all time pe
riods were also assessed. All analyses were adjusted for baseline risk
of being in pain and propensity to be in the intervention group. Over
all, 50.9% of patients reported some pain. After adjustment for other
variables associated with pain, comparing the intervention to the cont
rol group, there was not a statistically significant difference in lev
el of pain (OR for higher levels of pain 1.15; CI 1.00-1.32) or satisf
action with control of pain during the hospitalization (OR for higher
levels of pain 1.12; CI 0.91-1.39), 2 or 6 months after discharge, or
during the last 3 days of life, A multifaceted intervention using info
rmation, empowerment, advocacy, counseling and feedback was ineffectiv
e in ameliorating pain in seriously ill patients. Control of pain in t
hese patients remains an important problem. More intensive pain treatm
ent strategies addressing the needs of seriously ill hospitalized adul
ts must be evaluated. (C) 1998 International Association for the Study
of Pain. Published by Elsevier Science B.V.