ANTITUMOR EFFECT OF POLYSACCHARIDE COATED LIPOSOMAL ADRIAMYCIN ON AH66 HEPATOMA IN NUDE-MICE

Drug delivery systems play a crucial role in cancel chemotherapy, not only in the achievement of sufficient tumoricidal effect but also in m inimizing systemic side effects. We investigated the effect of liposom al adriamycin with tumor recognition molecule, 1-aminolactose (1-AL), on AH66 hepatoma transplanted into nude mice. Adriamycin (ADM) was enc apsulated in liposome coating with cholesterol pullulan (CHP) to incre ase the stability in the blood stream. 1-AL was assembled to the outer -layer of CHP-coated liposomal ADM as a tumor recognition molecule. In an in vivo therapeutic study, 1-AL/CHP-coated liposomal ADM restraine d tumor growth more when compared with CHP-coated liposomal ADM Thus, 1-AL/CHP-coated liposome seems to be a carrier of ADM to tumor cells.