GENOTOXICITY OF POLYCYCLIC MUSK FRAGRANCES IN THE SISTER-CHROMATID EXCHANGE TEST

The synthetic polycyclic musk fragrance compounds Galaxolide 6,6,7,8,8 -hexamethyl-cyclopenta-(g)-2-benzopyrane, Tonalide (7-acetyl-1,2,3,4,4 ,6-hexamerthyltetraline), Celestolide (4-acetyl-1,1-dimethyl-6-tert. b utylindane), Phantolide (6-acetyl-1,1,2,3,3,5-hexamethylindane), Cashm eran (6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H) indanone) and Traseolid e (5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane) are widely used as fragrance ingredients in perfumes, lotions and detergents; as food add itives in cigarettes and fish baits. Several studies identified polycy clic musk fragrances in aquatic environment samples, human milk and hu man adipose tissue as highly lipophil with human lymphocytes.