SUPERCOMPUTER DESCRIPTION OF HUMAN LUNG MORPHOLOGY FOR IMAGING ANALYSIS

A supercomputer code that describes the three-dimensional branching st ructure of the human lung has been developed. The algorithm was writte n for the Gray C94. In our simulations, the human lung was divided int o a matrix containing discrete volumes (voxels) so as to be compatible with analyses of SPECT images. The matrix has 3840 voxels. The matrix can be segmented into transverse, sagittal and coronal layers analogo us to human subject examinations. The compositions of individual voxel s were identified by the type and respective number of airways present . The code provides a mapping of the spatial positions of the almost 1 7 million airways in human lungs and unambiguously assigns each airway to a voxel. Thus, the clinician and research scientist in the medical arena have a powerful new tool to be used in imaging analyses. The co de was designed to be integrated into diverse applications, including the interpretation of SPECT images, the design of inhalation exposure experiments and the targeted delivery of inhaled pharmacologic drugs.