EFFICIENT SYNTHESIS OF THE GADOLINIUM COMPLEX OF A NEW C-2-SYMMETRICAL TETRAMINE

Authors
HARRE M NICKISCH K SCHULZ C WEINMANN H
Citation
M. Harre et al., EFFICIENT SYNTHESIS OF THE GADOLINIUM COMPLEX OF A NEW C-2-SYMMETRICAL TETRAMINE, Tetrahedron letters, 39(17), 1998, pp. 2555-2558
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
17
Year of publication
1998
Pages
2555 - 2558
Database
ISI
SICI code
0040-4039(1998)39:17<2555:ESOTGC>2.0.ZU;2-6
Abstract
A short and efficient synthesis of the substituted tetramines 2a and 7 and of the gadolinium complex 1 was developed starting from the Cbz-p rotected amino alcohol 3. Key steps of the synthesis are the optimized bleach oxidation of enantiopure alcohols and the bridging of the resu lting aldehyde molecules by double reductive amination with ethylenedi amine. Interesting biological activity of the amines 2a and 7 was dete cted. (C) 1998 Elsevier Science Ltd. All rights reserved.