SYNTHESIS AND RESOLUTION OF A CHIRAL ANALOG OF 2,2,6,6-TETRAMETHYLPIPERIDINE AND OF ITS CORRESPONDING NITROXIDE

Authors
EINHORN J EINHORN C RATAJCZAK F DURIF A AVERBUCH MT PIERRE JL
Citation
J. Einhorn et al., SYNTHESIS AND RESOLUTION OF A CHIRAL ANALOG OF 2,2,6,6-TETRAMETHYLPIPERIDINE AND OF ITS CORRESPONDING NITROXIDE, Tetrahedron letters, 39(17), 1998, pp. 2565-2568
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
17
Year of publication
1998
Pages
2565 - 2568
Database
ISI
SICI code
0040-4039(1998)39:17<2565:SAROAC>2.0.ZU;2-O
Abstract
The novel C-2 symmetric chiral amine trans-2,6-dimethyl-2,6-diphenylpi peridine has been synthesized via two successive nitrone nucleophilic addition-oxidation sequences, followed by reduction of the intermediat e nitroxide. hue enantiomers have been obtained via resolution with ma ndelic acid. (C) 1998 Elsevier Science Ltd. All rights reserved.