Antibiotic resistance is a worldwide concern. Over the past several de
cades, antibiotic resistance has increased to many respiratory pathoge
ns as well as aerobic gram-negative bacilli. Recently, methicillin-res
istant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococ
cus (VRE) have become important hospital pathogens. Antibiotic resista
nce is not related to a particular antibiotic structure and is not dep
endent upon mechanism of antibiotic action. The volume of use per se d
oes not increase antimicrobial resistance. This article discusses cont
rol strategies and identifies which antibiotics are associated with th
e emergence of resistant organisms.