PREOPERATIVE USE OF OCTREOTIDE IN A NEWBORN WITH PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY

In this paper, we describe a newborn diagnosed with persistent hyperin sulinemic hypoglycemia of infancy (PHHI) at two days of age. She prese nted with severe asymptomatic hypoglycemia and required both a high ra te of glucose infusion and diazoxide treatment, On the 9th hospital da y, due to persistent and intractable hypoglycemia, subcutaneous octreo tide treatment was initiated, This treatment reduced the rate and conc entration of glucose needed to be infused but the hypoglycemia did not subside totally. On the 18th hospital day near-total pancreatectomy w as performed. Tachyphylaxis resulting from continuous use of octreotid e limited its effect but enabled us to keep the patient euglycemic pre operatively.