Sn. Meydani et al., ANTIOXIDANT MODULATION OF CYTOKINES AND THEIR BIOLOGIC FUNCTION IN THE AGED, Zeitschrift fur Ernahrungswissenschaft, 37, 1998, pp. 35-42
The oxidant/antioxidant balance is an important determinant of immune
cell function, including maintaining integrity and functionality of me
mbrane lipids, cellular proteins, nucleic acids, and for control of si
gnal transduction and gene expression in immune cells. Optimal levels
of antioxidants are needed for maintenance of the immune response acro
ss all age groups. This need might be more critical, however, in the a
ged. Age-associated dysregulation of immune response, particularly of
cytokine production and T-cell-mediated function, is well documented.
The well-known age-related increase in free radical formation and lipi
d peroxidation contributes, at least in part, to this phenomenon. This
review will summarize animal and human studies undertaken by the auth
ors as well as those by other investigators on the effect of antioxida
nts, vitamin E, beta-carotene, and glutathione on cytokine production
and T-cell-mediated function in the aged.