SR-141716, A CB1 CANNABINOID RECEPTOR ANTAGONIST, SELECTIVELY REDUCESSWEET FOOD-INTAKE IN MARMOSET

SR 141716 (1 and 3 mg/kg p.o.), a selective central (CB1) cannabinoid receptor antagonist, selectively reduced feeding of a very highly pala table cane-sugar mixture in marmosets. In contrast, standard primate p ellet intake was not modified at the lower dose, but was slightly incr eased (+29%; p<0.01) by the higher dose of SR 141716. These results ar e in agreement with the hypothesis that endogenous cannabinoid systems are involved in the modulation of the appetitive value of food. (C) 1 998 Rapid Science Ltd.