IMMUNOHISTOCHEMISTRY OF BONE-MARROW BIOPSY

In a percentage of cases, conventional morphologic evaluation of bone- marrow needle biopsy (BMNB) in insufficient to achieve a firm diagnosi s. Under these circumstances, immunohistochemistry plays a basic role, providing an easy and objective key for the interpretation of the pat tern observed in most instances. Herein, the authors focus on the tech nical procedures, which allow extensive application of immunohistochem istry to the study of BMNB, as well as on the panels of antibodies nee ded for the identification of the most relevant conditions.