TETRAHYDRONAPHTHALENIC DERIVATIVES AS NEW AGONIST AND ANTAGONIST LIGANDS FOR MELATONIN RECEPTORS

Authors
FOURMAINTRAUX E DEPREUX P LESIEUR D GUARDIOLALEMAITRE B BENNEJEAN C DELAGRANGE P HOWELL HE
Citation
E. Fourmaintraux et al., TETRAHYDRONAPHTHALENIC DERIVATIVES AS NEW AGONIST AND ANTAGONIST LIGANDS FOR MELATONIN RECEPTORS, Bioorganic & medicinal chemistry, 6(1), 1998, pp. 9-13
Citations number
27
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
1
Year of publication
1998
Pages
9 - 13
Database
ISI
SICI code
0968-0896(1998)6:1<9:TDANAA>2.0.ZU;2-R
Abstract
Tetrahydronaphthalenic ligands were synthesized and evaluated as melat onin receptor ligands. Biological studies show that the aromaticity of the ring bearing the side chain is not essential for affinity and act ivity and that replacement of the methoxy group with the bioisostere e thyl which does not offer the possibility of H-bonding, leads to antag onist or forskoline potentiating properties. (C) 1998 Elsevier Science Ltd. All rights reserved.