LIPASE-CATALYZED SELECTIVE DEACETYLATION OF PHENOLIC ENOLIC ACETOXY GROUPS IN PERACETYLATED BENZYL PHENYL KETONES/

Authors
PARMAR VS PATI HN AZIM A KUMAR R",HIMANSHU,"BISHT KS PRASAD AK ERRINGTON W
Citation
Vs. Parmar et al., LIPASE-CATALYZED SELECTIVE DEACETYLATION OF PHENOLIC ENOLIC ACETOXY GROUPS IN PERACETYLATED BENZYL PHENYL KETONES/, Bioorganic & medicinal chemistry, 6(1), 1998, pp. 109-118
Citations number
43
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
1
Year of publication
1998
Pages
109 - 118
Database
ISI
SICI code
0968-0896(1998)6:1<109:LSDOPE>2.0.ZU;2-U
Abstract
Highly chemo-and regioselective de-esterification has been observed in the deacetylation of peracetylated enolic forms of polyphenolic benzy l phenyl ketones by lipase from porcine pancreas (PPL) suspended in te trahydrofuran (THF). The enzyme selectively deacetylates the enolic ac etoxy over the phenolic acetoxy group(s) and continuation of the react ion resulted, in addition the regioselective deacetylation of acetoxy function para to the nuclear carbonyl group. (C) 1998 Elsevier Science Ltd. All rights reserved.