Objective: To discuss informed consent to heart transplantation in the
case of an intensive care unit (ICU) patient: relatives' informed con
sent was refused by the patient himself whose cognitive ability appear
ed to be reasonable for the purpose. Setting: ICU of a university teac
hing hospital. Patient: a 62-year-old man who underwent myocardial rev
ascularization had in the immediate post-operative hemodynamic instabi
lity, continuous serious arrhythmias, ventilatory support, fentanyl in
fusion. Heart transplantation could be the only chance for his surviva
l. Intervention: heart transplantation. Results: despite patient's ref
usal, we decided to hold the relative's consent as valid, and transpla
ntation was accordingly performed, to the subsequent satisfaction of t
he patient. Conclusions: Our decision was based on two beliefs: (1) th
e severity of the patient's clinical condition may have impaired his c
ognitive abilities; (2) the very same conditions may mask impairment a
nd certainly make reliable assessment of cognition and judgment imposs
ible. This being so, the preservation of life assumes priority.